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KMID : 1059519980420020150
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Journal of the Korean Chemical Society
1998 Volume.42 No. 2 p.150 ~ p.155
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Kinetic Study on the Reaction of para-substitued Benzylbromide with Isoquinoline under High Pressure
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Kim Young-Cheul
Lim Jong-Wan
Choi Sung-Yong
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Abstract
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Kinetic studies on the reaction of isoquinoline with para-substituted benzylbromides were conducted under various pressures (1∼1000 bar) in acetonitrile. From the rate constants obtained, the activation parameters such as ΔV≠, Δβ≠, ΔH≠, ΔS≠, ΔG≠ and Ea were evaluated.Reaction rate increasing the pressure and temperature. The activation compressibility coefficient and the activation entropy showed negative values. From the substituent effect and the results, it was found that the reaction proceeds through SN2 mechanism, but the structure of transition state was slightly changed with substituents and pressure.
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KEYWORD
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